Kisspeptin-10 for Weight Loss

Biochemical Pathway and Mechanism of action:

Kisspeptin is a hypothalamic neuropeptide which has recently emerged as a central regulator of gonadotrophin secretion. Kisspeptin is for normal puberty, as evidenced by a failure to progress through puberty in individuals with mutations in genes encoding Kisspeptin and its receptor, GPR54. Numerous studies suggests that Kisspeptin acts directly on GnRH-containing neurons to stimulate GnRH secretion from the hypothalamus, this is a key component of the neuroendocrine pathway regulating ovulation as well as puberty, and that the kisspeptin-GPR54 system contributes to the modulatory impact of metabolism on reproductive function.

Clinical application based on research:

The two main areas of research with positive clinical outcomes are as follows;

Dosing Information:

  • Reference studies provided dosing at 0.3MCG/KG; for example, 0.3 MCG X 60KG weight = 180 MCG per dose or divided in 2 doses.
  • Compounded as 200MCG/mL in 5mL Multi-dose vial

Contraindications:

As the mechanism of action for Kisspeptin-10 (KP10) is similar to hCG, it is important to take the same given precautions when dealing with a patient that has been diagnosed with hormonal cancer(s). Additionally, neither pregnant nor nursing mothers should be administered KP-10. Both of these precautions stem from KP-10’s ability to change the body’s sexual hormone profile, specifically in regards to testosterone(s) and estrogen(s)

Common Side Effects:

It is an endogenously made chemical belonging to a group of peptides called Kisspeptins which are responsible for developing sexual organs at the time of puberty. As such, Kisspeptin-10 is generally considered safe if not abused or administered in large doses. Unless abused, there are little to no known side effects.