The Weight Loss Medication
That Outperforms Everything Else
Retatrutide's triple-receptor mechanism produced 24.2% average body weight loss in clinical trials — more than semaglutide and tirzepatide combined could claim. Physician-supervised therapy, personalized to you.
(Phase 2 trials, 48 wks)
targeted simultaneously
than comparable trials
Three Receptors. One Injection. Unprecedented Results.
Every other weight loss medication — including Ozempic, Wegovy, Mounjaro, and Zepbound — targets one or two hormone receptors. Retatrutide targets three simultaneously, engaging biology that no other drug can reach.
GLP-1
Appetite & Blood Sugar
Signals the brain to reduce hunger, slows gastric emptying, and regulates insulin after meals. The foundation of all modern weight loss medications.
Appetite ControlGIP
Metabolic Efficiency
Amplifies the insulin response after eating and enhances how efficiently your cells use glucose — the upgrade that made tirzepatide outperform semaglutide.
Enhanced MetabolismGlucagon
Fat Burn & Metabolic Rate
Instructs the liver to release stored energy and raises your resting metabolic rate — so your body burns more calories around the clock, even at rest.
The DifferentiatorRetatrutide vs. Semaglutide vs. Tirzepatide
If you've tried Ozempic, Wegovy, Mounjaro, or Zepbound — or if you're evaluating options for the first time — here's how the clinical evidence stacks up.
| Semaglutide (Ozempic / Wegovy) |
Tirzepatide (Mounjaro / Zepbound) |
Retatrutide Available at Regal |
|
|---|---|---|---|
| Receptors Targeted | GLP-1 only | GLP-1 + GIP | GLP-1 + GIP + Glucagon Best |
| Avg. Weight Loss | ~15% body weight | ~20% body weight | ~24.2% body weight Best |
| Trial Duration | 68 weeks (STEP 1) | 72 weeks (SURMOUNT-1) | 48 weeks — better results, faster |
| Resting Metabolic Rate | ✗ No effect | ✗ No effect | ✓ Increased via glucagon |
| Fat Breakdown (Lipolysis) | ✗ Indirect only | ✗ Indirect only | ✓ Direct activation |
| Administration | Weekly injection | Weekly injection | Weekly injection |
| Available at Regal WL | ✓ Yes | ✓ Yes | ✓ Yes (via compounding) |
Clinical trial results are from independent studies (STEP 1, SURMOUNT-1, Phase 2 TRIUMPH). Cross-trial comparisons should be interpreted with appropriate caution due to differences in study design and populations. All medications available subject to physician evaluation.
What the Phase 2 Data Actually Shows
The NEJM-published Phase 2 TRIUMPH trial enrolled 338 adults over 48 weeks — double-blind, placebo-controlled. The results were unlike anything previously recorded in weight loss pharmacotherapy.
Phase 2 results are from a double-blind, placebo-controlled study (Jastreboff et al., NEJM 2023). Retatrutide is not yet FDA-approved; it is available through licensed compounding pharmacies under physician supervision. Individual results will vary. Regal Weight Loss physicians evaluate all patients before recommending any medication.
Who Is Retatrutide Right For?
Retatrutide is not right for everyone — and matching the right therapy to the right patient is exactly what a Regal Weight Loss physician consultation is designed to determine. That said, here's a general picture of who tends to be the best fit.
✓ Strong Candidates
- BMI ≥ 30, or BMI ≥ 27 with a weight-related condition (high blood pressure, type 2 diabetes, sleep apnea, high cholesterol)
- Patients who plateaued on semaglutide (Ozempic / Wegovy) and want more
- Patients who responded to tirzepatide but want to push further
- Those with insulin resistance, elevated triglycerides, or metabolic syndrome — glucagon activation is particularly beneficial here
- Higher starting BMI (40+) requiring a medication with evidence for substantial, sustained loss
- Motivated, committed patients ready for a physician-supervised program
→ Important Considerations
- Not appropriate for patients with personal or family history of medullary thyroid carcinoma (MTC)
- Not appropriate for Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
- Not for use during pregnancy or in patients planning to conceive in the near term
- History of pancreatitis requires physician evaluation before starting any GLP-1 class medication
- Our physicians will review your complete medical history before any recommendation is made — eligibility is determined case by case
Physician-Supervised. Personalized. Proven.
Retatrutide is a powerful tool — but its results depend entirely on how it's managed. At Regal Weight Loss, every patient receives a program built around their specific health profile, not a one-size-fits-all protocol.
Comprehensive Medical Evaluation
Full health history review, baseline labs, and metabolic assessment before any prescription is written. We treat you as an individual, not a number on a scale.
Licensed DFW Physicians
Our physicians stay at the leading edge of obesity medicine — including retatrutide — so our patients always have access to the most advanced, evidence-based options available.
Ongoing Monitoring & Dose Management
Supervised escalation, regular follow-ups, lab tracking, and responsive dose adjustments — the difference between results and disappointment is how well-managed your therapy is.
Personalized Protocol — Not a Template
Your starting dose, escalation timeline, and maintenance plan are built around your body — not a generic protocol. Individualized dosing is what separates outcomes at Regal from cookie-cutter programs.
All Three Options Under One Roof
Semaglutide, tirzepatide, and retatrutide — all available. Our physicians will recommend what's right for you, not simply what's newest or most popular.
Long-Term Maintenance Planning
We don't stop at goal weight. Every Regal patient receives a thoughtful long-term maintenance strategy to protect and sustain the results they've worked to achieve.
Frequently Asked Questions
Our physicians answer these questions every day. Here are the most common ones — but your best answers will come in a one-on-one consultation.
Ready to Explore What
Retatrutide Can Do for You?
Schedule a free consultation with a Regal Weight Loss physician. We'll review your health history, answer every question you have, and build a program perfectly suited to you — whether that's retatrutide or another evidence-based approach.